4-ACO DMT

Description

Buy 4-ACO DMT Online
Buy 4-ACO DMT Online, O-Acetylpsilocin is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.

Buy 4-ACO-DMT Online (also known as O-Acetylpsilocin, 4-Acetoxy-DMT, or Psilacetin) is a synthetically produced psychedelic tryptamine. It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT. The compound has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies as they are both believed to be prodrugs of psilocin.[1] Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile and the three compounds can be said to feel indistinguishable from each other. This allows 4-AcO-DMT to function as a perfect substitute for psilocybin mushrooms.

Buy B4-ACO DMT Online and several other esters of psilocin were originally patented on January 16, 1963, by Sandoz Ltd. via Albert Hofmann & Franz Troxler. Despite this fact, 4-AcO-DMT remains a psychedelic with a limited history of use prior to its release as a grey area compound on the online research chemical market.

There are, however, claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin.[4] Some users report that it lasts slightly longer than psilocin while others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by 4-AcO-DMT more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if 4-AcO-DMT is active itself and not merely as a prodrug.

4-Acetoxy-N,N-dimethyltryptamine, also known as psilacetin, is a semi-synthetic serotonergic psychedelic drug. It is structurally similar to psilocybin, the active compound found in magic mushrooms. This compound is believed to be a prodrug of psilocin, meaning it is converted into psilocin in the body, which then exerts its psychoactive effects .

Mechanism of Action

Biochemical Pathways
Upon ingestion, 4-Acetoxy-N,N-dimethyltryptamine is believed to be deacetylated into psilocin, a psychoactive compound . This process involves the cleavage of the acetoxy group, a reaction that is likely facilitated by enzymes known as esterases . The resulting psilocin then interacts with the 5-HT2A receptor, triggering a series of downstream effects that alter various neurological processes.

Pharmacokinetics
It is believed that the acetoxy group enhances the compound’s lipid solubility, potentially aiding in its ability to cross the blood-brain barrier .

Result of Action
The activation of the 5-HT2A receptor by this compound leads to a range of effects at the molecular and cellular level. Users often report experiences similar to those produced by psilocybin, but without some of the unpleasant side effects associated with natural mushrooms, such as nausea . .

Action Environment
The action of this compound can be influenced by various environmental factors. For instance, the presence of other compounds, such as those found in certain psychedelic candies, can potentially alter the effects of this compound

Biochemical Analysis

Cellular Effects
4-Acetoxy-N,N-dimethyltryptamine influences various types of cells and cellular processes. It has been shown to affect cell signaling pathways, gene expression, and cellular metabolism. In particular, it binds to 5-HT2A receptors on the surface of neurons, leading to altered neurotransmitter release and changes in synaptic plasticity . This binding can result in the activation of downstream signaling pathways, which may influence gene expression and cellular metabolism. The compound’s effects on cellular function include changes in neurotransmitter levels, modulation of synaptic activity, and alterations in neuronal connectivity .

Temporal Effects in Laboratory Settings
In laboratory settings, the effects of this compound can change over time. The compound’s stability and degradation are important factors to consider. Studies have shown that this compound is relatively stable under controlled conditions, but it can degrade over time, especially when exposed to light and heat . Long-term effects on cellular function have been observed in both in vitro and in vivo studies. These effects include changes in synaptic plasticity, alterations in neurotransmitter levels, and modulation of gene expression .

Dosage Effects in Animal Models
The effects of this compound vary with different dosages in animal models. At low doses, the compound produces mild psychoactive effects, while higher doses can lead to more pronounced alterations in perception and cognition . Threshold effects have been observed, with certain dosages required to elicit specific responses. Toxic or adverse effects at high doses include nausea, vomiting, fast heart rate, anxiety, agitation, lightheadedness, and tremor . These effects highlight the importance of careful dosage control in both research and potential therapeutic applications.

Transport and Distribution
The transport and distribution of this compound within cells and tissues are critical for its activity. The compound is thought to cross the blood-brain barrier, allowing it to reach the central nervous system . Within cells, it may interact with transporters and binding proteins that facilitate its movement and localization. The distribution of this compound can affect its concentration in different tissues, influencing its overall effects on the body .

Subcellular Localization
The subcellular localization of this compound is important for its activity and function. The compound is believed to localize primarily in the cytoplasm and at the cell membrane, where it can interact with receptors and other biomolecules . Targeting signals and post-translational modifications may direct this compound to specific compartments or organelles, influencing its activity and function within the cell .

Preparation Methods

4-Acetoxy-N,N-dimethyltryptamine can be synthesized by acetylating psilocinThe acetylation can be carried out under alkaline or strongly acidic conditions . Industrial production methods typically involve advanced organic chemistry techniques and access to specific reagents and equipment .

Chemical Reactions Analysis

4-Acetoxy-N,N-dimethyltryptamine undergoes several types of chemical reactions, including:

Deacetylation: In vivo, this compound is deacetylated to psilocin by enzymes such as esterases.

Oxidation and Reduction: These reactions can occur under specific conditions, although detailed studies on these reactions for this compound are limited.

Substitution: The compound can undergo substitution reactions, particularly at the indole ring structure.

Common reagents used in these reactions include acids, bases, and various organic solvents. The major product formed from the deacetylation reaction is psilocin.

Scientific Research Applications

4-Acetoxy-N,N-dimethyltryptamine has gained interest in scientific research as a potential alternative to psilocybin for studying its therapeutic effects on various conditions such as depression, anxiety, and addiction . It is also used in pharmacological studies to understand the effects of serotonergic psychedelics and their potential therapeutic applications .

Comparison with Similar Compounds

4-Acetoxy-N,N-dimethyltryptamine is often compared to other similar compounds such as:

Psilocybin: Both compounds are prodrugs of psilocin, but psilocybin contains a 4-phosphoryloxy group instead of a 4-acetoxy group.

4-Acetoxy-DET: This compound is another psychedelic tryptamine with similar effects but contains a diethyl group instead of a dimethyl group.

4-Acetoxy-MET: Similar to this compound but with a methyl group instead of a dimethyl group.

The uniqueness of this compound lies in its structural similarity to psilocybin and its potential as a more cost-effective substitute for pharmacological studies .
You can as well Buy 5-MEO DMT